Serena & Blair in Gossip Girl

Blair and Serena are the two central characters of both the Gossip Girl series of novels and the television adaptation. In both, the two often power struggle as they deal with growing up but maintain their relationship as best friends for life. In the books, Blair and Serena are described as the two most beautiful girls on the Upper East Side. However, Serena seems to always end up the center of attention, something that bothers Blair to no end. The relationship between Blair and Serena, also known as B and S, is the relationship between series protagonists Blair Waldorf and Serena van der Woodsen.

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